Human Lin28 Forms a High-Affinity 1:1 Complex with the 106~363 Cluster miRNA miR-363
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چکیده
منابع مشابه
Human Lin28 Forms a High-Affinity 1:1 Complex with the 106~363 Cluster miRNA miR-363
Lin28A is a post-transcriptional regulator of gene expression that interacts with and negatively regulates the biogenesis of let-7 family miRNAs. Recent data suggested that Lin28A also binds the putative tumor suppressor miR-363, a member of the 106~363 cluster of miRNAs. Affinity for this miRNA and the stoichiometry of the protein-RNA complex are unknown. Characterization of human Lin28's inte...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2016
ISSN: 0006-2960,1520-4995
DOI: 10.1021/acs.biochem.6b00682